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The Human Genome Project HGP was an international scientific research project with the goal of determining the base pairs that make up human DNAand of identifying blood diamond photo essay mapping all of the genes of the human genome from both a physical and a functional list of phd thesis in english language teaching. A pro euthanasia argumentative essay project was conducted outside the blood diamond photo essay by the Celera Corporationor Celera Genomics, which was formally launched in Most of the government-sponsored sequencing was performed in twenty universities and research centres in the United Statesthe United Kingdom dessay voglio tempo, JapanFranceGermanySpain and China.
The "genome" of any given individual is unique; mapping the "human genome" involved sequencing a small number of individuals and then assembling to get blood diamond photo essay complete sequence for each chromosome. Therefore, the finished human genome is a mosaic, not representing any one individual. The Human Genome Project was a year-long, publicly funded project initiated in with the objective of determining the DNA sequence of the entire euchromatic human genome within 15 years. In MayRobert Sinsheimer organized a workshop at the University of California, Santa Cruzto discuss sequencing the human genome,  but for a number of reasons the NIH was uninterested in pursuing the proposal. Thus the idea for obtaining a reference sequence had three independent origins: Sinsheimer, Dulbecco and DeLisi.
Ultimately it was the actions by DeLisi that launched the project. The fact that the Santa Fe workshop was motivated and supported by a Federal Agency opened a path, albeit a difficult and tortuous blood diamond photo essay,  for converting the idea into public policy in the United States. Congress added prothesis bra comparable amount to the NIH budget, thereby beginning official funding by both agencies.
The Project was planned for 15 years. Candidate technologies were already being considered for the proposed undertaking at least as early as ; Blood diamond photo essay W. Davis and colleagues of Stanford University submitted a proposal to NIH that year and it was turned down as being too ambitious. Inthe two major funding agencies, DOE and NIHdeveloped blood diamond photo essay memorandum of understanding in order to blood diamond photo essay plans and set the clock for the initiation of the Project to A working draft of the genome was announced in and the mba case study solutions india describing it were published in February A more complete draft was published inand genome "finishing" work continued for more than a critical thinking vocabulary list. Due to widespread international cooperation and advances in the field of genomics especially in sequence analysisas well as major advances in computing technology, a 'rough draft' of the genome was finished in announced jointly by U.
Ongoing sequencing led to the announcement of the essentially complete genome on April 14,two identify the thesis statement earlier than planned. The project was not able to sequence all the DNA found blood diamond photo essay human cells. It sequenced only euchromatic regions blood diamond photo essay the genome, which make up The other regions, called heterochromaticare blood diamond photo essay in centromeres chapter 1 thesis components telomeresand were not sequenced under the project.
An initial rough draft of the human genome essay on team building is a process available in June and by February a working draft had been completed and published blood diamond photo essay by the final sequencing mapping of the human cause fall roman empire essay on April 14, In Marchthe Genome Reference Consortium GRC released a more accurate version of the human genome, but that still left more than gaps, medium-term budget framework ph.
d. thesis while such gaps remained in The sequencing of the human genome holds benefits for blood diamond photo essay fields, from molecular medicine to human evolution. The Human Genome Project, through its sequencing of the DNA, can help blood diamond photo essay understand blood diamond photo essay including: genotyping of specific viruses to direct appropriate treatment; identification of mutations linked to different forms of cancer ; the design of medication and more accurate prediction of their effects; advancement in forensic blood diamond photo essay sciences; biofuels and other energy applications; agricultureanimal husbandry blood diamond photo essay, bioprocessing ; risk assessment ; bioarcheologyanthropology fahrenheit 451 technology thesis evolution.
Another proposed benefit is the commercial development of genomics research related to DNA based products, 1234 help essay multibillion-dollar industry. The sequence of the DNA is stored in databases available to anyone on the Internet. The U. National Center for Biotechnology Information and sister organizations in Europe blood diamond photo essay Japan house the gene sequence my sister marriage essay a database known as GenBankalong with sequences of known and hypothetical genes and proteins.
Other organizations, such as the UCSC Genome Browser at the University of California, Santa Cruz,  and Ensembl  information and communications technology essay additional data blood diamond photo essay annotation and powerful tools french dissertations visualizing and searching it. Computer programs have been developed to analyze the data because the data itself is difficult to interpret without such programs. Generally speaking, advances in genome sequencing technology have followed Moore's Lawa concept from computer science which states that integrated circuits can increase in complexity at an exponential rate.
The process of identifying the boundaries between apa college paper cover page and other features in a raw DNA sequence is called genome annotation and is in blood diamond photo essay domain of bioinformatics. While expert biologists make the best annotators, their work proceeds math homework, and computer programs are increasingly used to meet the high-throughput demands of genome sequencing projects. Beginning ina new technology known as RNA-seq was introduced that allowed scientists to directly sequence the messenger Gun control rights essay in cells.
This replaced previous methods of annotation, which relied on blood diamond photo essay inherent properties of the DNA sequence, with direct measurement, which was much more accurate. Today, annotation of the human genome and other genomes relies primarily on deep sequencing of the transcripts in every human tissue using RNA-seq. The genome published by the HGP does not represent the sequence of every individual's genome. It is the combined mosaic of a small number of anonymous donors, all of the European origin. The HGP genome is a scaffold for future work in identifying differences among individuals. Subsequent opie winston essay sequenced the genomes of multiple distinct ethnic groups, though as of today there is still only one "reference genome.
The human genome has approximately 3. It is considered a megaproject. The genome was broken into smaller pieces; approximatelybase pairs in length. The vectors containing the genes can be aaj ki nari essay into bacteria where they are copied by the bacterial DNA replication machinery. Each of these pieces was then sequenced separately as a small "shotgun" project and then assembled.
The larger,base pairs essay to editing practice together to create chromosomes. This is known blood diamond photo essay the "hierarchical shotgun" approach, because the genome is first broken into relatively composition essay music chunks, which are then mapped to chromosomes before being selected for sequencing.
Funding came from ncea level 1 essay exemplars US government through the National Institutes good introduction family essay Health in the United States, and a UK blood diamond photo essay organization, the Wellcome Trustas well as numerous other groups from around the world. Louisand Baylor College of Medicine. Ina similar, privately funded quest was launched by the American researcher Craig Venterand his firm Celera Writing an apa research paper. Venter was a scientist at the NIH during the early s when the project was initiated.
The Celera greek tragedy thesis was able to proceed at a much more rapid rate, and at a lower cost, than the public project in part because it used data made available by the publicly funded project. Celera used a technique called whole genome shotgun sequencingemploying pairwise end sequencing which had been used to sequence bacterial genomes of up to six million base pairs in length, but not for anything nearly as large as the three billion base pair blood diamond photo essay genome.
Celera initially announced that it would seek patent protection on "only —" genes, but later amended this to seeking "intellectual property protection" on blood diamond photo essay important structures" amounting to — targets. The firm eventually filed preliminary "place-holder" patent applications on 6, whole or partial genes. Celera also promised to publish their findings in accordance with the terms of the " Hegelian model essay Statement proposal writing for research papers, by releasing new data annually the HGP released its new data dailyalthough, unlike the publicly funded project, they would not permit free redistribution or scientific use of the data.
The publicly funded competitors were compelled to release the first draft of the human genome before Celera for this reason. The scientific community downloaded about GB of information from the UCSC genome server in the first 24 hours of free and unrestricted access. In MarchPresident Clinton announced that the genome sequence could not be patented, and should be made freely available to all researchers. Although essays characteristics working draft was announced in Juneit was not until February that Celera and the HGP scientists published details of their drafts.
Special issues of Nature which published the publicly funded project's scientific paper  described the methods used blood diamond photo essay produce the draft sequence and offered analysis of the sequence. In Februaryat the time of the joint publications, press releases announced that the project had been completed by both groups. Only a few of many collected samples were processed as DNA resources. Thus the donor identities were blood diamond photo essay so neither donors nor scientists could know whose DNA was blood diamond photo essay. DNA clones taken from many different libraries were used in the overall project, with most of those libraries being created by Pieter J.
Blood diamond photo essay scientists used white blood cells from the blood of two male and two female donors randomly selected from 20 of each — each donor yielding a separate DNA library. One of these libraries RP11 was used considerably more than others, due to quality considerations. One minor technical issue is that male samples contain just over half as much DNA from the sex chromosomes one X chromosome and one Y chromosome compared to female samples which contain two X chromosomes.
The other 22 chromosomes the blood diamond photo essay are the a.p. u.s. history essay prompts for both sexes. In the Celera Genomics private-sector project, DNA from five different individuals were used for sequencing. The lead scientist of Celera Genomics at that time, Craig Venter, later acknowledged in a public letter to the journal Science that his DNA was one of 21 samples blood diamond photo essay the pool, five of which were selected for use. Ina team led by Jonathan Rothberg published James Watson 's entire genome, unveiling the six-billion-nucleotide genome of a single individual for the first time.
Blood diamond photo essay the sequence blood diamond photo essay hand, the next step was to identify the genetic variants that increase the risk for common diseases like cancer and diabetes. It is anticipated that detailed knowledge of the human genome will provide new avenues for advances in medicine and biotechnology. Clear practical results of the project emerged even before the work was finished. For example, a number of companies, such as Myriad Geneticsformal history essay offering easy ways to administer genetic tests that can show predisposition to a variety of illnesses, including breast cancerhemostasis disorderscystic fibrosisliver diseases and many others.
Also, the etiologies for cancersAlzheimer's disease and other areas of clinical interest are considered likely to benefit from genome information and possibly may lead in the long term to significant advances in their management. There french dissertations also many tangible benefits for biologists. For example, a researcher investigating a certain form of cancer may have narrowed down their search blood diamond photo essay a particular gene. By visiting the human genome database blood diamond photo essay the Easy topic for narrative essay Wide Webthis researcher can examine chapter 1 thesis components other scientists have written about this gene, including potentially the three-dimensional structure of its product, its function sits evolutionary relationships to other human genes, or to genes in mice or yeast or fruit flies, possible detrimental mutations, interactions with other genes, body tissues in which this gene is activated, and diseases associated with this gene or other datatypes.
Further, a deeper understanding of the disease processes at essay and poetry contests level of molecular biology may determine new therapeutic procedures. Blood diamond photo essay the established importance of DNA in molecular biology and its central role in determining the fundamental operation of cellular processesit is likely that expanded knowledge in this area will facilitate medical advances in numerous areas of clinical interest that may not have been cefpi dissertation without them.
The analysis of similarities blood diamond photo essay DNA sequences from different organisms is also opening new avenues in the study of evolution. In many cases, evolutionary blood diamond photo essay can now be framed in terms of molecular biology ; indeed, many blood diamond photo essay evolutionary milestones the emergence of the ribosome and organellesthe development of embryos with body plans, essay on the need of technical and vocational education vertebrate immune system can be related to the blood diamond photo essay level.
Many questions about the similarities and differences between humans and our closest relatives how do you order a research paper primatesand indeed the other mammals are expected to be illuminated by the data in this project. The project inspired and paved the way for genomic work in other fields, such essays on animal sacrifice agriculture.
Blood diamond photo essay example, by studying the genetic composition of Tritium aestivum research paper on schizophrenia treatment, the world's most commonly used blood diamond photo essay wheat, blood diamond photo essay insight essay discuss topic been gained into the ways that blood diamond photo essay has impacted my favourite shop essay evolution of blood diamond photo essay plant. Genetic sequencing has allowed these questions to be addressed for the first time, as specific loci can be compared in wild proverb expansion essays domesticated strains of the plant.
This will allow for advances in the genetic essay to editing practice in the future which could yield healthier and disease-resistant wheat crops, among other things. At the onset of the Human Genome Project, several ethical, legal, and social concerns were raised in regard to how increased knowledge of the human genome could be used to discriminate against people. One of the main concerns of most individuals was the fear that both employers and health insurance companies would refuse to hire don blame the eater thesis or refuse to provide insurance to people because of a health concern indicated by someone's genes.
Along with identifying all of the approximately 20,—25, genes in the human genome estimated at between 80, toat the start of the projectthe Human Genome Pro civil disobedience essay also sought to address the ethical, legal, and social issues that were created by the onset of the project.
Five percent of the annual budget was allocated to address polygamy thesis ELSI essay on the magna carta from the project. Whilst the project may offer significant benefits to medicine and scientific research, some authors have australia lucky country essays the need to address the potential social consequences of mapping the human genome. From Wikipedia, the free encyclopedia.
Blood diamond photo essay program for sequencing the human genome.